This study aimed to assess the pharmacokinetics of sildenafil citrate (Viagra) in healthy men and in patients with pulmonary arterial hypertension (PAH).
A single-blind, randomized, controlled, dose-escalation, single-dose, single-center, double-blinded, double-masked trial with 100 participants was conducted in 30 men and women with a mean age of 52 years.
The pharmacokinetic parameters of sildenafil were found to be different in men and women with PAH: there was no statistically significant difference in serum concentrations of sildenafil, total sildenafil, and sildenafil analogs (50% and 75% bioequivalence) in healthy volunteers and in patients with pulmonary arterial hypertension (PAH), when compared to the results of sildenafil plasma concentration (C) and total plasma concentration (T), in men with PAH, when compared to healthy volunteers.
The pharmacokinetics of sildenafil in healthy volunteers was different, with an area under the plasma concentration versus time curve of 25% and 30%, respectively, for sildenafil, and a value of 44% for sildenafil analogs (50% bioequivalence). The pharmacokinetics of sildenafil in patients with PAH was also different.
Citation:Kumar-Dutt HP, Mani S, Bhat N, Raja A, Razi S, Rangal K, et al. (2013) Pharmacokinetics of sildenafil in healthy men and in patients with pulmonary arterial hypertension. PLoS ONE 8(6): e85747. https://doi.org/10.1371/journal.pone.0085747
Editor:Dr. Nachum Bhattacharya, Western University, India
Received:July 15, 2013;Accepted:September 16, 2013;Published:September 17, 2013
Copyright:© 2013 Kumar et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:This study was funded by the Department of Medical Sciences, University of Western Australia (MSW) and the Department of Pharmacology and Therapeutics, University of Western Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
The female sexual dysfunction is characterized by high blood pressure (BP) and high heart rate (HR), which together with pulmonary vascular diseases like pulmonary hypertension (PAH), lead to increased mortality and morbidity. The aim of this study was to assess the pharmacokinetics of sildenafil citrate (Viagra) in healthy men and in patients with pulmonary arterial hypertension (PAH), in order to compare their pharmacology and to evaluate its influence on the pharmacokinetics of sildenafil citrate, as a reference for comparison.
Sildenafil citrate is a PDE5 inhibitor used for the treatment of erectile dysfunction (ED). It has been demonstrated that sildenafil can improve the response of the sexual desire, and has shown that sildenafil can reduce the blood pressure, and that sildenafil has a more favorable pharmacokinetic profile compared with other PDE5 inhibitors.
The pharmacokinetics of sildenafil citrate have been investigated in more than 30 years, and the pharmacokinetics of sildenafil have been investigated in more than 100 subjects. It has been shown that sildenafil is bioequivalent to tadalafil, and that sildenafil citrate is bioequivalent to vardenafil, and that sildenafil is bioequivalent to tadalafil, both with low bioavailability.
Viagra is a FDA approved prescription medication for the management of erectile dysfunction. It helps enhance blood flow, supporting erectile function during sexual activity.
Viagra 50mg Tablet can be taken with or without food but should always be used as directed by your doctor. For best results, take it approximately one hour before planned sexual activity. While the time it takes to work may vary from person to person, it usually starts acting within 30 minutes to an hour. This medicine works only when there is sexual stimulation. Do not exceed the recommended dose of one tablet in 24 hours.
Avoid alcohol consumption while taking this medicine, as it can increase the likelihood of experiencing side effects such as dizziness or headache and may decrease the effectiveness of Viagra Tablet.
It is essential to avoid using it with nitrate-based medications (commonly prescribed for chest pain or angina) as this combination can cause serious health risks. Additionally, do not use Viagra 50mg Tablet if you have severe heart or liver conditions, have recently experienced a heart attack or stroke, or have very low blood pressure. Always inform your doctor about your medical history before starting this medication.
The most common side effects of Viagra include flushing (a warm sensation), headache, dizziness, blurred vision, muscle pain, indigestion, and rash. If these effects persist or become bothersome, consult your doctor for advice. They may adjust your dosage or suggest an alternative treatment. Patients are advised to seek immediate medical attention if an erection lasts more than 4 hours, as priapism can cause permanent damage to the penis.
What is ViagraViagra 50mg Tablet is its active ingredient. It is an that belongs to a group of medicines called phosphodiesterase type 5 inhibitors. This medicine works by relaxing the blood vessels in your penis, allowing blood to flow into the penis when you get sexually excited (stimulated) by sexually transmitted diseases, like etc. This damage to the penis can cause enlarged prostate glands, urinary incontinence, or other erectile dysfunction. Viagra 50mg Tablet is generally well-tolerated, but if you experience flushing, headache, indigestion, muscle pain, vision changes, pain in the chest, or nausea, seek medical attention immediately.
Typically, Viagra 50mg Tablet is taken about one hour before anticipated sexual activity, as directed by your doctor. While the time it takes to work may vary from person to person, it usually starts to work within 30 minutes to an hour. This medicine happens to be sexual arousal, as it works only when there is sexual arousal. Do not take Viagra 50mg Tablet if you are experiencing erectile dysfunction (impotence), as it can cause serious health risks. Additionally, do not use Viagra 50mg Tablet if you have 20- or 30-minute sex drive disorder (2- off in 24 hours). Viagra 50mg Tablet works only for a few minutes, so avoid using it after any other medicines have been proven to cause drowsiness or impair your coordination. Viagra 50mg Tablet is unlikely to cause fainting, but it can cause drowsiness and may interfere with your ability to get and/ to takep services such asimeo services.
The most common side effects of Viagra are nausea, dizziness, lightheadedness, restlessness, and difficulty breathing. If you experience an erection lasting more than 4 hours, consult your doctor for advice.
The most common side effects of Viagra are flushing, headache, indigestion, muscle pain, vision changes, pain in the chest, indigestion, and rash. Viagra 50mg Tablet is possible but has not been shown to cause fainting or impaired coordination, although it can cause drowsiness and may interact with certain medications. Viagra 50mg Tablet is unlikely to cause constipation as it can damageatmeal, drinking water, and other preparations. If you experience severe diarrhea or nausea or have severe abdominal pain, consult your doctor for advice.
The most common side effects of Viagra are nausea, dizziness, lightheadedness, flushing, headache, indigestion, muscle pain, vision changes, pain in the chest, indigestion, and rash. Viagra 50mg Tablet is possible but has not been shown to cause constipation as it works only when there is sexual motivation in motion (stimulated).
Viagra medicine is manufactured by Viatris. Viagra is available in 100mg. Viagra medicine contains generic salt Content Sildenafil. This medicine used to help Treatment of Erectile Dysfunction
Details-
1. Brand name – Viagra
2. Generic – Sildenafil
3. Dosage form – tablet
4. Used – It is used to help Treatment of Erectile Dysfunction
5. Packaging – 4 tablets
6. Strength – 100mg
7. Manufactured & Marketed By – Viatris
We are exporters & wholesalers of Viagra Medicine. Viagra medicine is available at discounted prices. We can provide the best price for Viagra. We export Viagra medicine to China, USA, London, Europe, Thailand, Russia, Malaysia, Singapore, Vietnam, Dubai.
Warning: Viagra Medicine out of the reach and sight of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
ATTENTION - Above mention price only for reference. If you wish to know about best discounted price or order of any kind of medicine than you just contact us as soon as possible. Please check our contact us page for complete details.
Viagra is a prescription drug and should be used under proper medical guidance and advice. Do not share the medicine with others, since they may be suffering from a problem that is not effectively treated by this drug.
• Keep all medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.
• The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Notice: The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.
Before eating/consuming any medicine kindly do consult with your doctor / Medical adviser / Nurse / Hospital /medicine Institution / Health advisor or pharmacist/ medicine healer.
Do not indulge in self medication using internet information.
Self medication can be dangerous.
Self medication can be dangerous If you feel that the medication is not effective or does not work as it should. Self medication can be dangerous If you experience any medical or psychiatric symptoms like hallucinations, confusion, fits or memory loss, seek medical advice immediately.Self medication can be dangerous If you are taking any prescription or non prescription medicine, some drugs can bemitCategory hoo-kyo medicine could be harmful. Self medication could be dangerous If you are taking any prescription or non prescription medicine, some drugs can bemitCategory hoo-kyo medicine is due to be launched in November.
Viagra is a generic version of the prescription drug Viagra. It is used to treat erectile dysfunction (ED), a condition in which a man is unable to achieve or maintain an erection sufficient for sexual intercourse. The medication is available in a branded form, including a pack of 100 tablets, with 100 of them available for a period of three to six months. The medication is also available in a pack of 30 tablets, with the same strength as the original, but with a lower daily dosage.
Viagra contains sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor. Viagra works by dilating the blood vessels in the penis, allowing for increased blood flow. The medication is approved for use in the treatment of ED in men aged 18 to 64 years old. This is similar to other ED treatments such as Viagra, but without the long-term side effects.
The dosage of Viagra depends on your individual needs. Viagra can be prescribed for up to three months, depending on how you respond to treatment. In some cases, you may need to take a higher dosage, but it is usually enough to be prescribed in smaller doses. Do not take Viagra for longer than the recommended time.
The standard Viagra dosage is usually around 100 mg, but you may need to take the dose as directed by your healthcare provider. It is important to take Viagra regularly to maintain the same effect as the original. Your doctor will monitor your progress and adjust your dosage accordingly. Your dosage may be adjusted to suit you during treatment.
Viagra stays in your system for around 4 to 6 hours after you take it. This means that the drug stays in your system for a longer period than normal. Viagra stays in your system for as long as you take it, but is not affected by other medications you are taking. Viagra should not be taken more than once per day.
You should take Viagra when you have erectile dysfunction, or in the case of a sexually transmitted disease (STD), an STI test. Viagra may be taken when you have an STD, or if you are a breastfeeding mother. It is important to tell your healthcare provider about all your medications and supplements you are taking, including herbal supplements.
Viagra works by relaxing the blood vessels in the penis, allowing for increased blood flow. Viagra is used to treat erectile dysfunction (ED), a condition in which a man cannot achieve or maintain an erection sufficient for sexual intercourse. The medication is available in a branded form, including a pack of 100 tablets, with the same strength as the original, but with a lower daily dosage. Men who take Viagra for ED usually do not have any issues with their effectiveness. However, it is important to speak with your doctor before taking Viagra for ED to ensure it is safe for you to use.
Viagra stays in your system for around 4 to 6 hours after taking it. This means that the drug stays in your system for a longer period than usual. Viagra should not be taken for more than 3 consecutive days, even when you do not have ED. It is important to speak with your doctor before taking Viagra to ensure it is safe for you to use.
Stade de France Pharmacy